New Research in Germany - using a modified enzyme to kill HIV - gives new hope. This comes after earlier expectations foundered early in December 2013 involving two patients in Boston.
Researchers at Boston hopes to cure two patients through bone marrow transplantation, following the case of a patient in Germany. Known as the Berlin patient, patient man became the only known person cured of HIV after passing through bone marrow transplants.
However, two patients with Boston, the virus re-emerged after undetected for months.
Enzyme-modified
Recent research in Germany could open another path. By utilizing a modified enzyme to recognize and kill HIV in human cells, Professor Joachim Hauber Heinrich Pette Institute - Leibniz Institute for Experimental Virology (HPI) said he and his team are working "to reverse the infection at the cellular level."
The modified enzyme called Tre Recombinase .
" The problem with HIV is so infect human cells , the viral genome will be integrated into the human genome , and this is why the researchers for failing to eliminate the infection , " said Hauber .
After testing the enzyme in cell cultures , experimental animals turn to .
Modified laboratory mouse blood , so the mice are infected with HIV .
Then the experimental enzyme , Tre Recombinase , inserted into the blood of mice . Tre Recombinase target cells of HIV -infected mice and eliminate the virus from the cell .
Tre Recombinase specifically targeted Long Terminal Repeat ( LTR ) in HIV - 1 .
LTR is the process of HIV - 1 to multiply in human cells . Enzyme stop the replication process and the ' cut ' of HIV from cells . HIV attaches itself to the cell , thus effectively eliminate them from the cell and the means to decide on life-giving cells the virus will die .
Researchers hope the same can be achieved in humans through stem cell therapy .
First of all they will take the patient's blood . Then they enter into the blood Tre Recombinase earlier . And finally , the blood is returned to the patient's body .
By using the patient's own stem cells , scientists hope they can prevent the patient's body rejected the blood is modified when re- inserted .
" Over time , blood will come out of the peripheral blood cells containing the molecules ' cutter ' and can eliminate the virus , and it is expected , the immune system of patients who have returned function will kill the remnants of infected cells , " said Hauber .
combining methods
Although still in its early stages , other researchers interested in the findings in this research .
Dr. . Asier Saez Cirion , a researcher with HIV / AIDS at the Pasteur Institute in Paris , assess the unique way of being taken to overcome the problems caused due to HIV while sticking to human cells .
" It was one of the first direct approach I see that aims to eliminate the virus from the cells in a specific way , " said Cirion .
But he warned that the success of curing mice infected only be ' a proof of concept . ' New real optimism will come from tests on humans .
But to cure HIV , Hauber agree that it is best to combine different methods - for example , a method that reduces the number of HIV-infected cells combined with treatments to boost immunity .
" In general , when we talk about healing - completely eliminating the virus - a virus that no longer exists in the patient's body , then it is best through a combination of several approaches , " said Hauber .
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