Tuesday 24 December 2013

Cheating Drug Development Insect Immune System

Since the beginning of the millennium, Asian ladybugs multiply rapidly in Germany, local ladybird population shifts. The advantages of this kind being investigated for drug development.


Asian ladybugs , caterpillars and beetles Europe . The third animal has many advantages . Andreas Vilcinskas insect expert at the University of Gießen revealed , the three most successful in evolution .


" Success is certainly no cause. One of them , the insects are able to produce molecules that can fight the enemy or enzymes that can adapt to the food sources . Diversity of these molecules we studied for the benefit of humans , " said Vilcinskas .
Where the most potential candidate ? Number one : Asian Ladybug . Just like ladybugs Europe , its main prey are aphids .
The researchers found the recipe for success breeding Asian ladybugs . Asian ladybugs poisonous blood , to not preyed upon by other insects .
" The idea , comparing the types of invasive like Asian ladybugs , and compare with the immune system that are not invasive . Way that we found something , " said the researcher .
Against tuberculosis and malaria
At first the Asian ladybird blood or hemo - limfositnya extracted . Ladybug stay alive despite the rotation given moment . Blood samples were smeared on ladybugs agar layer . Then for 24 hours put warm closet .
The results are amazing . Harmonin element of blood ladybugs do not allow bacteria to live . " Harmonin had our trials , and fights germs of tuberculosis and malaria as well . Nowadays active ingredient that can be used to develop drugs tuberculosis or malaria , " said Vilcinskas .
Candidate number two : caterpillars , which are immune gangrene . These caterpillars have enzymes that kill the pests . Back Vilcinskas explains : " A molecule of these caterpillars , are now in the stage of clinical research for the development of new drugs with unique efficacy . "
Researchers from the University of Gießen Mark Salzig with biotechnology experts molecular trigger for growth in a bioreactor , the condition is the same as in similar installations in the industry . Active ingredients antibiotikanya then affixed to the agar .



Still in the development stage

Salzig had to explain where research goes, "We've pretty much relative. Soon we will test the shell model. Pharmacy, but still takes a while, before being able to use the stage."

"Although there is a large pharmaceutical company that expressed interest, and develop together until the final product," he added.

Candidate number three: Beetle gravediggers. The researchers studied how these insects preserve food. If you find dead rats, beetles will bury it, coat it with saliva, so that food was preserved.

Researchers continue to pursue the beetles bury themselves prefer this. "We tried, how can obtain the beetle enzymes. Those food industry and the techniques are very attractive," says Andreas Vilcinskas.

No winners. Clearly, many insects have advantages that can be exploited. Scientists just have to carefully and patiently to find it.
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